Table 2.

Strategies to minimize bleeding risk in patients with significant thrombocytopenia

• Avoid non-steroidal anti-inflammatory drugs

• Avoid glycoprotein IIb/IIIa inhibitors

• Utilize a proton pump inhibitor unless contraindicated

• Aspirin should be used in low-dose form

• If a patient is already receiving a long-term anticoagulation agent, triple therapy should be avoided

• If a patient is undergoing percutaneous coronary intervention:

○ Radial approach preferred to femoral approach

○ Restrict dual antiplatelet therapy to 1 month post-stent

○ Second generation drug-eluting stent preferred to bare-metal stent