Table 2.
Association of replicated SNPs with different CKD aetiologies in the GCKD study
| CKD aetiology (leading cause) | n | % biopsy proven | rs17830558 (PLA2R1) |
rs9272729 (HLA-DQA1)a |
||||
|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P-value | OR | 95% CI | P-value | |||
| MNb | 137 | 100 | 1.63 | 1.23–2.15 | 5.0 × 10−4 | 6.86 | 4.55–10.34 | 6.4 × 10−24 |
| Lupus nephritisb | 104 | 100 | 1.10 | 0.82–1.47 | 5.2 × 10−1 | 3.00 | 1.90–4.72 | 2.8 × 10−6 |
| Diabetes mellitus, type 1 | 89 | 3.4 | 0.76 | 0.55–1.05 | 9.2 × 10−2 | 2.69 | 1.67–4.34 | 6.9 × 10−5 |
| FSGSb | 139 | 100 | 0.87 | 0.66–1.14 | 3.1 × 10−1 | 2.36 | 1.56–3.57 | 5.1 × 10−5 |
| Membranoproliferative GNb | 36 | 100 | 1.36 | 0.85–2.19 | 1.9 × 10−1 | 2.15 | 1.10–4.22 | 3.5 × 10−2 |
| Minimal change GNb | 53 | 100 | 1.30 | 0.87–1.94 | 2.0 × 10−1 | 1.70 | 0.90–3.22 | 1.2 × 10−1 |
| Interstitial nephritis | 135 | 19.3 | 0.98 | 0.75–1.29 | 9.1 × 10−1 | 1.56 | 1.00–2.43 | 5.3 × 10−2 |
| Nephrosclerosis | 1087 | 7.9 | 0.97 | 0.82–1.15 | 7.4 × 10−1 | 1.47 | 1.10–1.96 | 7.8 × 10−3 |
| Diabetes mellitus, type 2 | 649 | 4.2 | 0.89 | 0.74–1.07 | 2.0 × 10−1 | 1.38 | 1.02–1.87 | 3.3 × 10−2 |
| Renal artery stenosis | 47 | 0 | 1.32 | 0.87–2.00 | 1.9 × 10−1 | 1.29 | 0.64–2.62 | 4.9 × 10−1 |
| Wegener's granulomatosisb | 77 | 100 | 0.93 | 0.67–1.31 | 6.9 × 10−1 | 1.18 | 0.66–2.13 | 5.8 × 10−1 |
| IgA nephropathyb | 308 | 100 | 1.02 | 0.83–1.25 | 8.6 × 10−1 | 1.14 | 0.79–1.63 | 4.8 × 10−1 |
| Autosomal dominant polycystic kidney disease | 170 | 1.8 | 1.07 | 0.83–1.37 | 6.2 × 10−1 | 1.13 | 0.73–1.77 | 5.8 × 10−1 |
| Tumour nephrectomy | 61 | 11.5 | 0.91 | 0.63–1.32 | 6.2 × 10−1 | 1.07 | 0.55–2.08 | 8.4 × 10−1 |
| Analgesic nephropathy | 52 | 3.8 | 1.12 | 0.76–1.67 | 5.6 × 10−1 | 1.03 | 0.49–2.16 | 9.4 × 10−1 |
| Acute kidney injury | 59 | 10.2 | 0.90 | 0.61–1.32 | 5.9 × 10−1 | 1.02 | 0.50–2.08 | 9.5 × 10−1 |
| Micropolyangiitisb | 54 | 100 | 0.82 | 0.55–1.22 | 3.3 × 10−1 | 0.52 | 0.20–1.33 | 1.4 × 10−1 |
| Rapidly progressive GN, pauci-immuneb | 25 | 100 | 0.72 | 0.41–1.29 | 2.7 × 10−1 | 0.45 | 0.11–1.88 | 2.2 × 10−1 |
| KDIGO-defined CKD (all GCKD participants) | 4960 | 25.8 | 0.99 | 0.86–1.15 | 9.1 × 10−1 | 1.50 | 1.16–1.94 | 1.3 × 10−3 |
P-values that are statistically significant after correction for multiple testing are in bold type (P-value < 2.6 × 10−3 = 0.05/19).
aIn GCKD, the proxy SNP rs2187668 was genotyped.
bAnalysis based on patients with biopsy-proven (leading) cause only because the proportion of available biopsy results was >70%.