Table 3.
Correlations Between Irritant Potencies in Zebrafish and Mutagenic Potencies in Salmonellaa in Response to the Same Extracts
| C-DEPb | F1b | F2b | F3b | F4b | r2 for Fish Potency Versus Mutagenic Potency/Strain | P-Value | |
|---|---|---|---|---|---|---|---|
| Potency in zebrafish (cm/μg EOM/ml) | 2.43 | 0.11 | 4.96 | 11.35 | 1.79 | — | — |
| Mutagenic potency in TA100-S9c (Rev./μg EOM) | 13.10 | 0.00 | 41.30 | 60.40 | 8.00 | 0.93 | .0085 |
| Mutagenic potency in TA98-S9d (Rev./μg EOM) | 7.50 | 0.00 | 18.00 | 23.20 | 4.30 | 0.88 | .019 |
| Mutagenic potency in TA98NR-S9e (Rev./μg EOM) | 4.70 | 0.00 | 12.80 | 17.50 | 2.40 | 0.90 | .013 |
| Mutagenic potency in YG1041-S9f (Rev./μg EOM) | 67.90 | 0.00 | 192.50 | 236.80 | 28.80 | 0.85 | .025 |
a
Mutagenicity potency values were obtained from Mutlu et al. (2013).
b
Data are slopes of linear regressions of dose-response data.
c
Sensitive to non-PAH base-substitution mutagens.
d
Sensitive to nitroarenes.
e
Sensitive to frameshift mutagens other than nitroarenes.
f
Sensitive to nitroarenes.
S9 is a supernatant fraction of a rat liver homogenate containing metabolizing enzymes; it is added to mimic mammalian metabolism of test substances since some mutagens require metabolism.
Rev., revertants.