Table 3.
N | OR | 95% CI | C-statistic | P-value | |
---|---|---|---|---|---|
Univariable | |||||
Age, per 1 year increase | 151 | 1.09 | (1.01–1.18) | 0.635 | 0.034 |
Gender, male vs. female | 151 | 6.46 | (1.45–28.72) | 0.643 | 0.014 |
Modified BMI, per 1 kg·dL/m2·g increase | 151 | 0.98 | (0.96–1.00) | 0.603 | 0.085 |
Coronary artery disease, yes vs. no | 151 | 1.89 | (0.70–5.08) | 0.568 | 0.210 |
Elevated BNPa, yes vs. no | 119 | 2.96 | (1.07–8.19) | 0.627 | 0.037 |
Systolic blood pressure, per 1 mmHg increase | 151 | 1.00 | (0.98–1.02) | 0.466 | 0.893 |
QRS duration, per 1 ms increase | 142 | 1.02 | (1.01–1.03) | 0.672 | 0.021 |
Albumin, per 1 g/dL increase | 151 | 0.55 | (0.22–1.36) | 0.597 | 0.195 |
Mean gradient, per 1 mmHg increase | 148 | 0.97 | (0.93–1.00) | 0.617 | 0.061 |
LVEF, per 1% decrease | 151 | 1.04 | (1.01–1.06) | 0.640 | 0.014 |
LA dimension, per 1 mm increase | 141 | 1.10 | (1.03–1.17) | 0.702 | 0.003 |
IVSD ≥1.2 vs. <1.2 cm | 147 | 4.10 | (1.52–11.03) | 0.664 | 0.005 |
SV index <35 vs. ≥35 mL/m2 | 147 | 4.53 | (1.68–12.21) | 0.676 | 0.003 |
Severe symptomatic AS stage | 0.605 | 0.058 | |||
Stage D2 vs. D1 | 148 | 3.66 | (1.26–10.64) | 0.017 | |
Stage D3 vs. D1 | 148 | 1.51 | (0.30–7.68) | 0.619 | |
MCF, per 1 unit decrease | 147 | 1.10 | (1.05–1.15) | 0.789 | <0.0001 |
Average mitral annular S’, per 1 cm/s decrease | 136 | 5.0 | (2.56–9.09) | 0.947 | <0.0001 |
E/A ratio, per 1 unit increase | 136 | 2.08 | (1.39–3.11) | 0.719 | 0.0004 |
Model selection: ‘final’ modelb | |||||
Average mitral annular S’, per 1 cm/s decrease | 136 | 5.0 | (2.56–9.09) | 0.719 | <0.0001 |
ATTR-CA, transthyretin cardiac amyloidosis; TAVR, transcatheter aortic valve replacement; OR, odds ratio; CI, confidence interval; BNP, brain natriuretic peptide; BMI, body mass index; LVEF, left ventricular ejection fraction; LA, left atrium; AS, aortic stenosis; IVSD, interventricular septum at diastole.
Elevated BNP was designated for patients if BNP ≥300 pg/mL or NT proBNP ≥2000 pg/mL.
The ‘final’ model shows the unanimous recommendations of several model building strategies (backward, forward, and stepwise) that considered all non-collinear predictors with P < 0.25 from univariable regression.