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(Transporters: hFR, human folate receptor; RFC, reduced folate carrier. MTX, methotrexate; MTX-PG, methotrexate-polyglutamated; DHF, dihydrofolate; DHFR, dihydrofolate reductase; THF, tetrahydrofolate; MTHFR, 5,10-methylenetetrahydrofolate reductase).
