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. 2018 Feb 7;9(14):11677–11690. doi: 10.18632/oncotarget.24433

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Copyright: © 2018 Tayyari et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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All matched pathways according to p values from pathway enrichment analysis and pathway impact values obtained from pathway topology analysis for (A) Metabolites that distinguished tumors and normal adjacent tissues for African Americans. A total of 39 pathways were found to be associated with the metabolites, of which 29 pathways were significant (p<0.05). Glycolysis or gluconeogenesis (1); pyruvate metabolism (2); alanine, aspartate and glutamate metabolism (3); glycine, serine and threonine metabolism (4); glutamine and glutamate metabolism (5); taurine and hypotaurine metabolism (6); (B) Metabolites that distinguished tumors and normal adjacent tissues for Caucasians. A total of 39 pathways were found to be associated with the metabolites, of which one pathway, pyrimidine metabolism (1) was significant. (see also Supplementary Table 1)