Table 1. 5-FU dose adaptation algorithm used in the present study and the one proposed by Gamelin.

AUC (mg.h/L )	5-FU Dose Adjustment (± % of previous dose)	Gamelin’s algorithm
<4	+70	+70
4 to < 8	+50	+50
8 to < 10	+40	+40
10 to <12	+30	+30
12 to < 15	+20	+20
15 to < 18	+10	+10
18 to < 20	Unchanged	+5
20 to < 24	Unchanged	Unchanged
24 to < 28	Unchanged	−5
28 to < 31	−10	−10
>31	−15	−15