Table 3. Frequency of evaluated toxicities at subsequent cycles.

	Cycle 1 (n = 155)			Cycle 2 (n = 154)			Cycle 3 (n = 118)
Toxicity	All grades	Grade I/II	Grade III/IV	All grades	Grade I/II	Grade III/IV	All grades	Grade I/II	Grade III/IV
Diarrhea	22.6% (35)	19.4% (30)	3.2% (5)	20.1% (31)	16.9% (26)	3.2% (5)	12.7% (15)	11.9% (14)	0.8% (1)
Hand-food syndrome	3.2% (5)	3.2% (5)	0% (0)	2.6% (4)	2.6% (4)	0% (0)	0% (0)	0% (0)	0% (0)
Neutropenia	9.7% (15)	3.9% (6)	5.8% (9)	6.5% (10)	1.3% (2)	5.2% (8)	7.3% (9)	5.1% (6)	2.5% (3)
Mucositis	8.4% (13)	5.2% (8)	3.2% (5)	6.5% (10)	6.5% (10)	0% (0)	2.5% (3)	2.5% (3)	0% (0)