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. 2017 Dec 15;9(14):11489–11502. doi: 10.18632/oncotarget.23727

Figure 3. Protein-protein functional associations involved in apoptosis and mestastasis.

Figure 3

The figure shows a schematic visualization of the action types and action effects concerning ENO1, PARK7, PTGES3, NPM1, SSBP1, STMN1 (pointed by black arrow) among themselves and other proteins, known and predicted, to be involved in apoptosis (Protein-Protein Interaction -PPI- enrichment p-value < 0,01) (A) and metastasis (PPI enrichment p-value < 0,01) (B), according to the STRING v10.5 (only interactions with confidence score >= 0.400 are shown). Line colours and shapes indicate reaction (black), binding (blu), catalysis (indigo), transcriptional regulation (green mint), activation (light green), post-translational modification (fuchsia), inhibition (red), positive effect (arrowhead), negative effect bar), and unspecified effect (dot). Finally, the thickness of grey lines indicates the strength of data support.