Table 2.

Potency of inhibitors with modifications on Ring C (R³) against both human sEH and human FAAH.

	R3	IC50 (nM)
		hsEH	hFAAH
t-TUCB		0.8	140
14		5	>10,000
15		4	1,100
16		3	5,800
17		4	5,300
18		2	120
19		3	>10,000
20		4	120
21		2	70
22		7	35
23		5	400
24		3	24
25		2	170
26		2	100
27		2	130
28		3	30
29		5	1,100