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. Author manuscript; available in PMC: 2019 Feb 15.
Published in final edited form as: Bioorg Med Chem Lett. 2018 Jan 4;28(4):762–768. doi: 10.1016/j.bmcl.2018.01.003

Table 4.

IC50 values of compounds t-TUCB, 18 and 24 on sEH and FAAH in multiple species.

IC50(nM)
Enzyme Species t-TUCB 18 24 PF-3845 URB597
FAAH Human 140 120 24 0.6 23
Mouse 6,300 350 510 12 11
Rat >10,000 1,700 >10,000 4.4 12
Cat 1,200 92 240 <0.1 12
Dog 3,900 280 280 0.4 22
Horse 3,300 270 87 0.3 7
sEH Human 0.8 2 3 - -
Mouse 5.7 0.4 2.1 - -
Rat 54 1.0 1.6 - -
Cat 2.0 4.3 42 - -
Dog 5.6 11 28 - -
Horse 19 21 77 - -