Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Metabolic stability of sEH inhibitors with substituents in bridgehead positions of adamantane against human microsomes (HLM).
| # | Amount remaining after 30 minutes in contact with HLM (%) |
T½ (min) | Clint* (µL.min−1.mg−1) |
|
|---|---|---|---|---|
| − NADPH | + NADPH | |||
| 147136 | 97 ± 8 | 69 ± 2 | 56 | 12 |
| 1b | 95 ± 3 | 64 ± 6 | 54 ± 3 | 13 ± 1 |
| 2b | 100 ± 3 | 8 ± 2 | 8 ± 1 | 84 ± 6 |
| 3b | 95 ± 4 | 0.7 ± 0.2 | 3.5 ± 0.3 | 196 ± 2 |
Intrinsic clearance
