Table 1.

Top common genetic variants associated with atrial fibrillation in African American, Chinese, European, Japanese, and Korean cohorts identified by genome-wide analysis

SNP	Locus	Closest gene	MAF (%)	RR (95% CI)	P-value
African American13
rs998259	14q22	GCH1	96.0	NA	3.59 × 10–6
rs4758417	11p15	HPX	98.0	NA	1.44 × 10–5
rs5436	17p13	SLC2A4	91.0	NA	3.16 × 10–5
rs93267	8p12	NRG1	92.0	NA	1.98 × 10–5
rs4246336	15p26	PCSK6	43.0	NA	3.8 × 10–4
rs4611994	4q25	PITX2	21.0	1.40 (1.16–1.69)	5.4 × 10–4
Chinese14,15
rs2200733	4q25	PITX2	64.6	1.81 (1.21–3.20)	1.3 × 10–10
rs3807989	7q31	CAV1	24.5	1.42 (1.20–1.68)	4.77 × 10–5
rs2106262	16q22	ZFHX3	39.0	1.32 (1.15–1.51)	1.97 × 10–4
European6,7
rs2200733	4q25	PITX2	25.8	1.71 (1.54–2.21)	6.1 × 10–41
rs12415501	10q24	NEURL	16.0	1.18 (1.13–1.23)	6.5 × 10–16
rs7193343	16q22	ZFHX3	17.6	1.25 (1.17–1.3)	1.8 × 10–15
rs13376333	1q21	KCNN3	29.5	1.56 (1.38–1.77)	6.3 × 10–12
rs3903239	1q24	PRRX1	44.7	1.14 (1.10–1.18)	9.1 × 10–11
rs10507248	12q24	TBX5	73.0	1.12 (1.08–1.16)	5.7 × 10–11
s3807989	7q31	CAV1	40.4	0.88 (0.84–0.91)	9.6 × 10–11
rs1152591	14q23	SYNE2	47.6	1.13 (1.09–1.18)	6.2 × 10–10
rs13216675	6q22	GJA1	68.0	1.10 (1.06–1.14)	2.2 ×10–9
rs6490029	12q24	CUX2	64.0	1.12 (1.08–1.16)	3.9 × 10–9
rs10821415	9q22	C9orf3	42.4	1.13 (1.08–1.18)	7.9 × 10–9
rs4642101	3p25	CAND2	65.0	1.10 (1.06–1.14)	9.8 × 10–9
rs7164883	15q24	HCN4	16.0	1.16 (1.10–1.22)	1.3 × 10–8
rs10824026	10q22	SYNPO2L	15.8	0.85 (0.81–0.9)	1.7 × 10–8
Japanese10
rs2220427	4q25	PITX2	45.0	1.71 (1.63–1.78)	1.65 × 10–134
rs21061	16q22	ZFHX3	31.0	1.33 (1.27–1.39)	9.63 × 10–36
rs6584555	10q24	NEURL	12.0	1.32 (1.26–1.39)	2.0 × 10–25
rs7698692	4q34	HAND2	54.2	1.17 (1.13–1.21)	1.21 × 10–21
rs17461925	1q32	PPFIA4	82.0	1.20 (1.15–1.25)	8.69 × 10–18
rs2047036	10q24	SH3PXD2A	28.4	1.16 (1.12–1.20)	4.04 × 10–16
rs2540953	2p14	SLC1A4-CEP68	67.4	1.15 (1.11–1.20)	2.06 × 10–15
rs12044963	1p13	KCND3	52.0	1.14 (1.10–1.17)	2.52 × 10–15
rs2296610	10p12	NEBL	14.5	1.20 (1.15–1.26)	1.51 × 10–14
rs1049334	7q31	CAV1	71.0	1.20 (1.15–1.26)	1.83 × 10–14
rs6490029	12q24	TBX5/CUX2	65.0	1.12 (1.08–1.16)	3.9 × 10–9
rs639652	1q24	PRRX1	54.0	1.13 (1.08–1.18)	4.43 × 10–9
rs13219206	6q22	GJA1-HSF2	72.0	1.14 (1.09–1.20)	3.52 × 10–8
Korean9
rs6817105	4q25	PITX2	52.5	2.43 (2.12–2.78)	6.01 × 10–38
rs2106261	16q22	ZFHX3	34.8	2.08 (1.83–2.36)	3.32 × 10–30
rs4615152	4q34	HAND2	42.0	1.51 (1.35–1.68)	1.43 × 10–12
rs11579055	1q32	PPFIA4	69.0	1.48 91.30–1.68)	2.29 × 10–9
rs3903239	1q24	PRRX1	54.3	1.14 (1.24–1.60)	1.25 × 10–7
rs6584555	10q24	NEURL	12.6	1.58 (1.33–1.88)	2.77 × 10–7
rs883079	12q24	TBX5	43.2	1.19 (1.05–1.35)	0.006

CI, confidence interval; MAF, minor allele frequency; NA, not available; RR, relative risk; SNP, single nucleotide polymorphism.