Table III.
Adverse events occurring in ≥15% of patients on siltuximab alone and with dexamethasone
| Patients with adverse event (%) | Siltuximab Alone (Treatment Plan A before Dexamethasone) N=14 |
Combination Siltuximab and Dexamethasone N=49 |
||||
|---|---|---|---|---|---|---|
| All | Gr3 | Gr4 | All | Gr3 | Gr4 | |
| Thrombocytopenia | 36 | 14 | 14 | 49 | 14 | 12 |
| Fatigue | 36 | 0 | 0 | 43 | 4 | 4 |
| Anaemia | 57 | 36 | 7 | 35 | 14 | 2 |
| Hepatic function abnormal | 14 | 0 | 0 | 31 | 6 | 2 |
| Neutropenia | 21 | 7 | 0 | 29 | 14 | 4 |
| Diarrhoea | 50 | 0 | 0 | 29 | 0 | 0 |
| Peripheral oedema | 0 | 0 | 0 | 29 | 0 | 0 |
| Dyspnea | 14 | 0 | 0 | 27 | 4 | 0 |
| Dizziness | 7 | 0 | 0 | 25 | 0 | 0 |
| Nausea | 29 | 0 | 0 | 22 | 0 | 0 |
| Leucopenia | 14 | 7 | 0 | 22 | 4 | 0 |
| Insomnia | 0 | 0 | 0 | 22 | 2 | 0 |
| Constipation | 7 | 0 | 0 | 20 | 0 | 0 |
| Weight increase | 0 | 0 | 0 | 20 | 2 | 0 |
| Myalgia | 7 | 0 | 0 | 16 | 0 | 0 |
| Enzyme abnormality | 0 | 0 | 0 | 16 | 0 | 0 |