Roles of miRNAs in the modulation of immunological mechanism of psoriasis. Both the cells interaction network and the cytokines and chemokines network are regulated by miRNA, which indicates a critical role of miRNA playing in the immunopathogenesis of psoriasis. KC, keratinocyte; imDC, immature dendritic cell; mDC, mature dendritic cell; LC, Langerhans cell; TC, T cell; NK, natural killer cell; NKT, natural killer T cell; Treg, regulatory T cell; miR, microRNA