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. 2017 Dec 5;43(2):131–142. doi: 10.1503/jpn.160219

Fig. 4.

Fig. 4

Multimodal meta-analysis of structural and functional abnormalities in drug-free patients with schizophrenia. The clusters with significant differences in both structural and functional changes between diagnostic groups mainly showed (A) decreased grey matter volume with hypoactivation in the bilateral posterior cingulate cortex (B. PCC), right inferior frontal gyrus (R. IFG), left inferior parietal gyrus (L. IPG), left cerebellum (hemispheric lobule IV/V, VI, crusI) and left caudate nucleus (L. caudate nucleus); (B) decreased grey matter volume with hyperactivation in the bilateral superior temporal gyrus (STG), left fusiform gyrus (L. FG) and right lingual gyrus (R. LG); (C) increased grey matter volume with hypoactivation in the superior frontal gyrus (SFG), left cerebellum (hemispheric lobule III) and right inferior parietal gyrus (R. IPG); and (D) increased grey matter volume with hyperactivation in the left insula (L. insula) and left cerebellum (hemispheric lobule IX).