Table 1.
Genes downregulated by Δ9-tetrahydrocannabinol and prevented by chaetocin coadministration
| Condition; mean ± SEM (n) | THC × chaetocin interaction | |||||
|---|---|---|---|---|---|---|
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| Gene | Vehicle | Chaetocin | THC | THC + chaetocin | F | p value* |
| Cnr1 | 0.000 ± 0.080 (11) | 0.515 ± 0.179 (5) | −0.652 ± 0.148 (10) | 0.954 ± 0.174 (7) | F1–29 = 14.1 | < 0.001 |
| Mgll | 0.000 ± 0.138 (11) | 0.059 ± 0.227 (5) | −0.720 ± 0.083 (11) | 0.469 ± 0.192 (7) | F1–30 = 13.43 | < 0.001 |
| Gria1 | 0.000 ± 0.110 (11) | −0.056 ± 0.248 (5) | −0.734 ± 0.124 (10) | 0.161 ± 0.122 (7) | F1–29 = 10.72 | 0.003 |
| Grin2a | 0.000 ± 0.101 (12) | −0.304 ± 0.093 (5) | −0.346 ± 0.116 (14) | 0.393 ± 0.187 (7) | F1–33 = 11.23 | 0.002 |
| Grin2b | 0.000 ± 0.074 (11) | −0.474 ± 0.123 (5) | −0.682 ± 0.115 (13) | −0.086 ± 0.172 (7) | F1–32 = 17.04 | < 0001 |
| Grm2 | 0.000 ± 0.175 (9) | −0.337 ± 0.157 (5) | −0.951 ± 0.196 (11) | 0.211 ± 0.267 (7) | F1–28 = 11.63 | 0.002 |
| Grm3 | 0.000 ± 0.076 (9) | −0.050 ± 0.102 (5) | −0.395 ± 0.084 (12) | 0.401 ± 0.272 (7) | F1–28 = 7.21 | 0.012 |
| Grm5 | 0.000 ± 0.085 (10) | 0.386 ± 0.158 (5) | −0.573 ± 0.129 (12) | 0.999 ± 0.212 (7) | F1–30 = 15.32 | < 0.001 |
| Gabbr1 | 0.000 ± 0.141 (11) | 0.050 ± 0.255 (5) | −0.657 ± 0.095 (11) | 0.336 ± 0.280 (6) | F1–29 = 6.88 | 0.010 |
| Gabra2 | 0.000 ± 0.102 (11) | 0.144 ± 0.173 (5) | −0.349 ± 0.109 (13) | 0.217 ± 0.254 (7) | F1–31 = 5.56 | 0.025 |
| Gad1 | 0.000 ± 0.151 (11) | −0.403 ± 0.111 (4) | −0.640 ± 0.082 (14) | −0.360 ± 0.425 (7) | F1–32 = 12.09 | 0.001 |
| Bdnf | 0.000 ± 0.104 (11) | 0.438 ± 0.213 (5) | −0.465 ± 0.148 (10) | 1.349 ± 0.234 (6) | F1–28 = 7.84 | < 0.001 |
| Dlg4 | 0.000 ± 0.528 (12) | 0.018 ± 0.209 (5) | −1.855 ± 0.376 (14) | 0.755 ± 0.195 (7) | F1–34 = 7.07 | 0.010 |
| Prkaca | 0.000 ± 0.052 (12) | 0.171 ± 0.177 (5) | −0.593 ± 0.085 (12) | 0.477 ± 0.348 (7) | F1–32 = 7.21 | 0.010 |
| Nos1 | 0.000 ± 0.113 (10) | −0.114 ± 0.103 (5) | −0.332 ± 0.101 (13) | 0.886 ± 0.757 (7) | F1–29 = 5.56 | 0.030 |
| Creb1 | 0.000 ± 0.099 (11) | −0.356 ± 0.181 (5) | −0.310 ± 0.103 (14) | 0.147 ± 0.191 (7) | F1–31 = 17.35 | < 0.001 |
| Homer1 | 0.000 ± 0.123 (11) | −0.267 ± 0.183 (5) | −0.928 ± 0.073 (11) | 0.194 ± 0.149 (7) | F1–30 = 28.56 | < 0.001 |
| Crebbp | 0.000 ± 0.119 (10) | −0.450 ± 0.189 (5) | −0.676 ± 0.131 (14) | 0.135 ± 0.195 (7) | F1–32 = 14.78 | < 0.001 |
| Reln | 0.000 ± 0.119 (10) | 0.129 ± 0.108 (4) | −0.894 ± 0.226 (12) | −0.210 ± 0.251 (7) | F1–29 = 23.33 | < 0.001 |
SEM = standard error of the mean; THC = Δ9-tetrahydrocannabinol.
*
THC + chaetocin v. THC; 2-way analysis of variance followed by Tukey multiple comparison test.