Table 2.
Genes downregulated by Δ9-tetrahydrocannabinol and not prevented by chaetocin coadministration
| Condition; mean ± SEM (n) | THC × chaetocin interaction | |||||
|---|---|---|---|---|---|---|
|
|
|
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| Gene | Vehicle | Chaetocin | THC | THC + chaetocin | F | p value* |
| Gria2 | 0.000 ± 0.074 (10) | 0.164 ± 0.133 (5) | −0.254 ± 0.050 (10) | 0.322 ± 0.160 (7) | F1–27 = 2.68 | 0.11 |
| Gabbr2 | 0.000 ± 0.099 (11) | 0.032 ± 0.157 (5) | −0.567 ± 0.079 (11) | 0.070 ± 0.373 (7) | F1–30 = 2.60 | 0.12 |
| Abat | 0.000 ± 0.227 (8) | −1.173 ± 0.398 (4) | −1.158 ± 0.183 (11) | −1.253 ± 0.402 (7) | F1–25 = 3.36 | 0.07 |
| Htr2a | 0.000 ± 0.273 (10) | −0.567 ± 0.128 (4) | −0.949 ± 0.175 (12) | −1.023 ± 0.314 (7) | F1–29 = 0.81 | 0.37 |
| Sirt1 | 0.000 ± 0.135 (10) | −0.503 ± 0.179 (5) | −0.523 ± 0.130 (13) | −0.356 ± 0.232 (6) | F1–30 = 3.80 | 0.06 |
| Pick1 | 0.000 ± 0.119 (9) | −0.370 ± 0.232 (5) | −1.121 ± 0.212 (12) | −0.614 ± 0.227 (6) | F1–28 = 4.00 | 0.06 |
| Pdyn | 0.000 ± 0.145 (11) | −0.191 ± 0.126 (4) | −0.541 ± 0.086 (13) | −0.211 ± 0.258 (6) | F1–30 = 2.46 | 0.13 |
| Synpo | 0.000 ± 0.052 (11) | 0.133 ± 0.196 (5) | −0.429 ± 0.107 (13) | −0.267 ± 0.522 (7) | F1–31 = 3.92 | 0.06 |
| Arc | 0.000 ± 0.229 (12) | −0.529 ± 0.632 (5) | −0.870 ± 0.181 (11) | 0.318 ± 0.336 (7) | F1–30 = 1.08 | 0.31 |
| Adcy1 | 0.000 ± 0.135 (11) | 0.154 ± 0.300 (4) | −1.040 ± 0.163 (14) | −0.114 ± 0.239 (7) | F1–32 = 3.34 | 0.08 |
SEM = standard error of the mean; THC = Δ9-tetrahydrocannabinol.
*
THC + chaetocin v. THC; 2-way analysis of variance.