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. Author manuscript; available in PMC: 2019 May 15.
Published in final edited form as: Neuropharmacology. 2017 Sep 5;134(Pt A):13–21. doi: 10.1016/j.neuropharm.2017.09.004

Figure 2.

Figure 2

Top panels – Thermoregulatory effects of 10 mg/kg MDPV following saline (circles), 10 mg/kg bupropion (triangles), 3 mg/kg desipramine (squares), or 3 mg/kg fluoxetine (diamonds) pretreatment at an ambient temperature of 20°C (left panel, white symbols) or 28°C (right panel, black symbols) in NIH Swiss mice (n=5–6). Abscissa: ‘BL’ denotes 30 min baseline data collected before injection, while ‘PT’ denotes data during the 30 min pretreatment. Numbers refer to time, in minutes, following MDPV administration. Ordinate: mean changes in core temperature from baseline values, analyzed in 30 min bins (± SEM). Lower panel – Thermoregulatory effects of MDPV following pretreatment with saline or a monoamine reuptake inhibitor at an ambient temperature of 20°C (white bars) or 28°C (black bars). Abscissa: ‘SAL,’ ‘Bupropion,’ ‘Desipramine,’ and ‘Fluoxetine’ represent data following pretreatments as described above. Ordinate: mean maximum change in core temperature from baseline values elicited by MDPV injection over 6 hr. Asterisks indicate significant difference from saline controls, p<0.05.