Thermoregulatory effects of three days of saline (top row), 100 mg/kg p-CPA (middle row), or 100 mg/kg α-MPT (bottom row) pretreatment, then of 10 mg/kg MDPV on day 4 (diamonds, all rows) at an ambient temperature of 20°C (left panels) or 28°C (right panels) in NIH Swiss mice (n=5–6). Abscissa: ‘BL’ denotes 30 min baseline data before injection. Numbers refer to time, in minutes, following MDPV administration. Ordinate: mean change in core temperature from baseline values, calculated in 30 min bins.