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. Author manuscript; available in PMC: 2019 May 15.
Published in final edited form as: Neuropharmacology. 2017 Sep 5;134(Pt A):13–21. doi: 10.1016/j.neuropharm.2017.09.004

Figure 6.

Figure 6

Top panels – Thermoregulatory effects of 10 mg/kg MDPV when preceded by 3 days of pretreatment with saline (circles), 100 mg/kg p-CPA (triangles), or 100 mg/kg α-MPT (squares) at an ambient temperature of 20°C (left panel, white symbols) or 28°C (right panel, black symbols) in NIH Swiss mice (n=5–6). Abscissa: ‘BL’ denotes 30 min baseline data before injection. Numbers refer to time, in minutes, following MDPV administration. Ordinate: mean change in core temperature from baseline values, calculated in 30 min bins. Lower panel – Maximum change in core temperature elicited by MDPV following pretreatment with saline or a monoamine synthesis inhibitor at an ambient temperature of 20°C (white symbols) or 28°C (black symbols). Abscissa: ‘SAL,’ ‘p-CPA,’ and ‘α-MPT’ represent MDPV challenge data in mice pretreated as described above. Ordinate: mean maximum change in core temperature recorded across the 6 hours immediately following MDPV administration. Number signs indicate significant difference between ambient temperature conditions, # = p<0.05; ### = p<0.001.