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. Author manuscript; available in PMC: 2020 Mar 16.
Published in final edited form as: Neurosci Lett. 2017 Sep 5;695:86–90. doi: 10.1016/j.neulet.2017.09.005

Table 1.

Expression of Cx and Panx proteins and their role in CNS cells.

Cell type Connexin/Pannexin expression Functions
Astrocytes Cx26[13], Cx30[14], Cx43[14] Cx GJs Adult neurogenesis[15], Glutamate transport[16], Glucose trafficking[17], Regulation of K+[18] and Na+[19] concentration
Panx1[20] Cx/Panx uHCs Neurotoxicity[21]
Neurons Cx36[14], Cx45[22], Cx50[23], Cx57[24] Cx GJs Electric and metabolic coupling[25], Spatial memory[26]
Panx1[20], Panx2[20] CX/Panx uHCs Electrical coupling[20], Neuronal development, adult neurogenesis[27], Synaptic plasticity[28]
Microglia Cx32[29], Cx36[30], Cx43[31] Cx GJs Do not express GJs under resting conditions
Panx1[32] Cx/Panx uHCs Glutamate release[29], Neurotoxicity[33], Inflammation[34]
Oligodendrocytes Cx29[35], Cx32[35], Cx45[36], Cx47[35] Cx GJs Maintenance of ionic homeostasis[37], Myelination[38]
Panx1[39] Cx/Panx uHCs Formation of uHCs has not been reported