Table 1.
Analysis of duodenal biopsies from control subjects, untreated CeD patients, and CeD patients subjected to gluten withdrawal.
| Characteristics | CeD | CeD-GFD |
|---|---|---|
| Number of cases and gender (female/male) | 10 (8/2) | 10 (7/3) |
| Median age, years (range) | 32 (18–56) | 37 (24–67) |
| Median time on a GFD, years (range) | – | 4 (2–14) |
| Number of cases with positive serology | ||
| IgA tissue transglutaminase > 20 UA/mL | 10 | 3 |
| Severity of histologic damage | ||
| (Marsh 3 classification) number of patients | 10 | 2 |
Demography, histological, and serology data of untreated (at diagnosis) celiac disease patients (CeD) and of CeD treated with gluten withdrawal (CeD-GFD) whose duodenal biopsies were employed for the study.
Patients were diagnosed with CeD according to conventional clinical, serological and histological criteria (108, 117). Control subjects: non-celiac subjects with negative CeD serology and normal duodenal histology, n = 10. Patients and controls were informed in detail about the study, and written consent was obtained. The protocols were approved by Ethics Committees of Hospital “Carlos B. Udaondo.”