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. 2018 Mar 1;9:173. doi: 10.3389/fphar.2018.00173

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Copyright © 2018 Wang, Xu, Li, Huang, Jiang, Wang, Liu, Leung and Yao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Inhibition of T1551 on PRMT5 methyltransferase activity. (B) Protein expression levels of H4R3me2s in A549 cell treated with T1551 at different concentrations (0, 2.5, 5.0, and 10.0 μM). (C) Densitometric analysis of band intensities of H4R3me2s. Western blot analysis was performed for 24 h, with at least three independent experiments. Data was presented as mean ± SEM (n = 3), with ^∗∗p < 0.01 for comparison between control group (DMSO-treated group) and T1551-treated group.