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. 2018 Mar 1;9:36. doi: 10.3389/fgene.2018.00036

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Copyright © 2018 de Sá Machado Araújo, da Silva Francisco Junior, dos Santos Ferreira, Mozer Rodrigues, Terra Machado, Louvain de Souza, Teixeira de Souza, Figueiredo Osorio da Silva, Alves da Silva, Andrade, da Silva, Ramos, Garcia, Machado and Medina-Acosta.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Absence of a tissue-specific histone modification enrichment signature at the PARD6G-AS1 and GCSAML iDMRs. Hierarchical clustering analysis of the histone modification enrichment profiles associated with maternal (A) gametic and (B) secondary iDMRs. The color intensity is correlated with the magnitude of the histone modification enrichment observed in tissues in which the genes are expressed either monoallelically or biallelically. Differential enrichment signatures in tissues with monoallelic expression are revealed for the GRB10, MEG8, and MAGEL2 iDMRs. The PARD6G-AS1 and GCSAML iDMRs were associated with contrasting chromatin segmentation marked by enrichment of activation and repression marks, respectively.