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. 2018 Mar 1;9:36. doi: 10.3389/fgene.2018.00036

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Copyright © 2018 de Sá Machado Araújo, da Silva Francisco Junior, dos Santos Ferreira, Mozer Rodrigues, Terra Machado, Louvain de Souza, Teixeira de Souza, Figueiredo Osorio da Silva, Alves da Silva, Andrade, da Silva, Ramos, Garcia, Machado and Medina-Acosta.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Secondary intermediate methylation status at the GCSAML predicted secondary promoter. Chromosome 1 ideogram; physical positions and domain features of the GCSAML locus displaying the methylation status at the CpG sites (golden ticks) across a 40 kb long-span view (hg19; chr1:247663350-247703349). The methylation levels are represented on a scale from 0 to 1 (hypomethylated to hypermethylated). The image is centered on the intronic CGI (GCSAML CGI-1 track) near the GCSAML predicted secondary promoter-flanking region. The light green ticks represent the positions of the CpG sites. The GCSAML locus overlaps two other annotated genes (GCSAML-AS1 and OR2C3). The annotated features (from top to bottom) are as in Figure 2. The methylation level across the CpG sites within the GCSAML candidate iDMR ranges from 0.35 to 0.65 in adult somatic tissues. In methylomes from male and female gametes and from blastocysts, this region is hypomethylated.