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. 2018 Mar 1;9:36. doi: 10.3389/fgene.2018.00036

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Copyright © 2018 de Sá Machado Araújo, da Silva Francisco Junior, dos Santos Ferreira, Mozer Rodrigues, Terra Machado, Louvain de Souza, Teixeira de Souza, Figueiredo Osorio da Silva, Alves da Silva, Andrade, da Silva, Ramos, Garcia, Machado and Medina-Acosta.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Intermediate mean methylation level across the PARD6G-AS1, PWWP2AP1, and GCSAML candidate iDMRs. Comparative variation in the average methylation levels across all 5^mCpG sites on the candidate iDMRs in the methylomes of healthy tissues depicted in Figures 2–4. In adult somatic tissues, the overall mean levels were 0.39 (PARD6G-AS1 iDMR), 0.42 (PWWP2AP1 iDMR) and 0.42 (GCSAML iDMR). A slightly skewed hypermethylation state (0.70) was observed in the liver for the PARD6G-AS1 iDMR. The three candidate iDMR regions are consistently hypermethylated in hESC-derived CD56⁺ ectoderm and mesoderm and hESC-derived CD184⁺ endoderm cell cultures. The light blue zone represents the expected intermediate methylation range (0.35–0.65). Each methylome is represented by a different color of bar.