Table 3.
Association between causes of peritoneal dialysis technique failure and all-cause mortality between 0–2 years post PD technique failure.
| Multivariate (HR) | Competing Risk (SHR) | |
|---|---|---|
| Causes of technique failure | ||
| Infection | 1.0 | 1.0 |
| Inadequate dialysis | 0.83 (0.70–0.98, 0.027) | 0.83 (0.70–0.98, 0.03) |
| Mechanical | 0.78 (0.66–0.93, 0.006) | 0.78 (0.66–0.93, 0.006) |
| Social | 1.46 (1.24–1.72, <0.001) | 1.47 (1.25–1.73, < 0.001) |
| Age# | 1.03 (1.03–1.04, <0.001) | 1.04 (1.03–1.04, <0.001) |
| Gender | ||
| Male | 0.95 (0.84–1.08, 0.44) | 0.94 (0.83–1.06, 0.33) |
| Race | ||
| Caucasian | 1.0 | 1.0 |
| Indigenous* | 0.95 (0.80–1.14, 0.60) | 1.00 (0.83–1.20, 1.00) |
| Other | 0.75 (0.63–0.90, 0.002) | 0.76 (0.64–0.92, 0.004) |
| Comorbidities | ||
| Lung disease | 1.16 (0.97–1.38, 0.10) | 1.17 (0.97–1.39, 0.09) |
| Coronary artery disease | 1.13 (0.99–1.28, 0.07) | 1.14 (1.00–1.30, 0.06) |
| Peripheral vascular disease | 1.16 (1.00–1.35, 0.05) | 1.17 (1.00–1.36, 0.05) |
| Cerebrovascular disease | 1.23 (1.04–1.46, 0.02) | 1.24 (1.04–1.48, 0.02) |
| Diabetes | 1.26 (1.02–1.56, 0.03) | 1.28 (1.03–1.59, 0.02) |
| Causes of ESKD | ||
| Glomerulonephritis | 1.0 | 1.0 |
| Diabetic nephropathy | 1.50 (1.17–1.92, 0.001) | 1.53 (1.20–1.96, 0.001) |
| Cystic kidney disease | 0.69 (0.50–0.95, 0.03) | 0.68 (0.49–0.94, 0.02) |
| Renovascular disease | 1.32 (1.07–1.62, 0.01) | 1.34 (1.08–1.65, 0.007) |
| Analgesic nephropathy | 1.31 (1.00–1.71, 0.05) | 1.32 (1.00–1.73, 0.05) |
| Other | 1.48 (1.23–1.77, <0.001) | 1.49 (1.24–1.80, <0.001) |
| Smoking history | ||
| Non-smoker | 1.0 | 1.0 |
| Current smoker | 1.25 (1.04–1.50, 0.02) | 1.29 (1.08–1.55, 0.006) |
| Ex-smoker | 1.00 (0.88–1.14, 0.99) | 1.01 (0.88–1.15, 0.92) |
| PD duration | ||
| </=1 year | 1.0 | 1.0 |
| 1–2 years | 1.37 (1.19–1.58, <0.001) | 1.32 (1.14–1.52, <0.001) |
| >2 years | 2.25 (1.92–2.63, <0.001) | 1.99 (1.70–2.33, <0.001) |
| PD modality | ||
| CAPD | 1.0 | 1.0 |
| APD | 0.99 (0.86–1.15, 0.93) | 1.00 (0.86–1.16, 1.00) |
| Era | ||
| 1990–1998 | 1.0 | 1.0 |
| 1999–2006 | 0.75 (0.64–0.87, <0.001) | 0.74 (0.63–0.86, <0.001) |
| 2007–2014 | 0.56 (0.47–0.66, <0.001) | 0.54 (0.45–0.63, <0.001) |
| BMI | ||
| Normal (18.5–24.9) | 1.0 | 1.0 |
| Overweight (25.0–29.9) | 0.76 (0.67–0.89, <0.001) | 0.77 (0.68–0.89, <0.001) |
| Obese (>30.0) | 0.80 (0.68–0.93, 0.005) | 0.81 (0.69–0.95, 0.009) |
| Underweight (<18.5) | 1.46 (1.07–1.98, 0.02) | 1.48 (1.08–2.04, 0.02) |
Data expressed as hazard ratio (95% confidence intervals, p-value). SHR- subdistribution hazard ratios. CAPD – continuous ambulatory peritoneal dialysis. APD – automated peritoneal dialysis.
#There was a significant interaction between age and causes of technique failure and the outcome of all cause mortality in the first 2 years post PD technique failure (p < 0.001).