Table 1.
Fold Change in Select Genes Associated with Myofibroblast Subpopulations.
| Gene Name | Gene Symbol | IPF-FC | Normal-FC |
|---|---|---|---|
| Alpha Smooth Muscle Actin | ACTA2 | 2.424* | 5.704 |
| Peroxisome proliferator activated receptor gamma | PPARG | 0.197* | 0.576 |
| Thy-1 membrane glycoprotein | THY-1 | 2.669* | 15.183* |
| S100 calcium-binding protein A4 | FSP1 | 0.394* | 0.374 |
| Connective tissue growth factor | CTGF | 3.101 | 4.348 |
| TGF-beta receptor type 1 | TGFBR1 | 1.154 | 1.516 |
| Collagen alpha 1(I) | COL1A1 | 0.969 | 2.803 |
| Transcription factor 19 | SC1 | 1.766 | 1.659 |
| Fibroblast Growth Factor Receptor 1 | FGFR1 | 2.353 | 2.768 |
Changes in gene expression of genes typically selected to identify subpopulations of myofibroblasts from heterogenous populations. Statistically significant fold changes are denoted with an * as determined by SAM (FDR = 0%; delta = 0.30).