Table 2.
Functional annotation clustering of genes differentially expressed in IPF-F as they adapt to the in vitro environment.
| Annotation cluster | Gene Ontology (GO) Term Summary | Enrichment Score | Gene Count | P Value |
|---|---|---|---|---|
| 1 | Mitochondrion | 4.91 | 161 | 1.40E-08 |
| 2 | Proteolysis | 4.66 | 137 | 1.70E-03 |
| 3 | ER-Golgi Transport | 4.62 | 31 | 1.54E-05 |
| 4 | ER | 4.15 | 131 | 1.69E-02 |
| 5 | Membrane-enclosed lumen | 3.94 | 233 | 7.09E-06 |
| 6 | tRNA processing | 3.41 | 38 | 1.60E-04 |
Functional annotation analysis reveals significant mitochondria involvement in IPF-F adaptation to the in vitro environment. Summary of the most significant functional categories altered in the IPF-F as they transition into the in vitro environment (Enrichment score greater than 3.0). Fold change and annotations for the highest clusters are found in Tables S4 and S5.