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. 2018 Mar 5;8:3993. doi: 10.1038/s41598-018-22148-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Genetic interaction analysis between miRNAs and their possible mRNAs targets for KOC (A), BMFC (B) and BMFC + KOC (C) groups. (D) Functional enrichment analysis of differentially expressed genes. (E) Validation of potential target genes of previously validated miRNAs. Arc: activity-regulated cytoskeleton-associated protein; Cbr3: carbonyl reductase 3; Tshz3: teashirt zinc finger homeobox 3; Pla2g5: phospholipase A2 group V; Htr2c: 5-hydroxytryptamine receptor 2 C; Mrps23: mitochondrial ribosomal protein S23; Sst: somatostatin; Satb2: SATB homeobox 2; Ip6k1: inositol hexakisphosphate kinase 1; Capn7: calpain 7. BMFC: buttermilk fat concentrate rich in phospho- and sphingolipids; KOC: krill oil concentrate rich in omega-3 fatty acids (eicosapentaenoic acid and docosahexaenoic acid) and phospholipids; BMFC + KOC: combination of BMFC and KOC.