Table 3.
Effect of weight loss (P < 0.05, lFDR < 0.2) on fasted state (T0, FC) metabolite concentrations and postprandial mixed meal challenge response (iAUC) in plasma of abdominally obese subjects
| Metabolites | P | FC(WL) | P(iAUC) |
|---|---|---|---|
| Amino acids and related metabolites | |||
| Glycine | < 0.01 | 1.18 | |
| Creatinine | < 0.01 | 0.88 | |
| Glutamine | < 0.01 | ||
| Histidine | < 0.01 | ||
| Creatine | < 0.01 | ||
| Pyroglutamic acid | < 0.01 | ||
| Glutamic acid | < 0.01 | 0.66 | |
| Oxylipins | |||
| TXB2 | < 0.01 | ||
| PGE2 | < 0.01 | ||
| 12S.HHTrE | < 0.01 | ||
| 5.HETE | < 0.01 | ||
| 11.HETE | 0.02 | ||
| TCA cycle and related metabolites | |||
| Glucose | 0.01 | ||
| Acylcarnitines | |||
| Choline | 0.01 |
Differences in postprandial response were determined on the basis of iAUC
FC fold change (T0, after weight loss/T0, before weight loss), iAUC incremental area under the curve significant at P < 0.05