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. 2018 Mar 5;8:4011. doi: 10.1038/s41598-018-22295-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MRI imaging & processing. Mean diffusivity (MD; A,C) and fractional anisotropy (FA; B,D) maps were calculated from 42-direction dMRI. Data was also visualised as RGB and line vector maps of diffusion directions (E,F). Diffusion metrics were calculated for two of the CA1 hippocampal layers (CA1sp and CA1sr) and two of the DG hippocampal layers (DGgl and DGml), illustrated in G. Variations in mean diffusivity (H), radial diffusion (I) parallel diffusion (J), fractional anisotropy (K), and apparent fibre density (L) were assessed, showing significant differences between the DGgl and other layers. *p < 0.05, **p < 0.01, ***p < 0.001.