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. 2018 Mar 5;8:4011. doi: 10.1038/s41598-018-22295-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differences in diffusion in hippocampal subregions. (A,B) Cellular imaging of the hippocampus shows regional variation in microstructure. Example voxels from each hippocampal region are outlined in (A), and showed at higher magnification in (B). DAPI (cell nuclei), PV (interneuron population) and GFAP (astrocytes) are differentially distributed within the CA1sp, CA1sr, DGgl and DGml cell layers. (C) Mean diffusivity correlates with DAPI staining area, reflective of cell density. (D) Mean diffusivity also correlates with axonal density. (E) Fractional anisotropy only correlates with astrocytes staining density, as shown with GFAP. (F) Axonal density, quantified from neurofilament staining area, negatively correlated with apparent fibre density in the hippocampal subregions examined.