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. 2018 Mar 5;8:3990. doi: 10.1038/s41598-018-22400-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Treatment with CLCF1 or VLDL efficiently decreased oxygen-induced pathological neovascularization. C57BL/6 WT mice were subjected to OIR and injected intravitreally at P12 with CLCF1 (intravitral concentration 100 ng/mL), VLDL (intravitral concentration 10 μg/mL), a combination of CLCF1 and VLDL or vehicle. Results are expressed as percentage of (A) vaso-obliterated or (B) neovascular area versus the whole retinal area. Histograms bars represent mean value of percentage, and dots represent individual values ± SEM. (C) Representative retinal flatmount images are shown in with vaso-obliterated areas delimited with dotted line. (D) Representative retinal flatmount images are shown with pre-retinal neovascularization outlined. Scale bars: 500 µm.