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. 2017 Sep 12;77(15):1677–1686. doi: 10.1007/s40265-017-0815-0
The first and only single-chain recombinant FVIII molecule in which the heavy and light chains are covalently linked to improve stability and affinity for VWF
Provides effective haemostatic efficacy across all age groups, with the majority of bleeds controlled with one injection
Prophylactic use is associated with low median spontaneous, overall and traumatic annualized bleeding rates in patients of all ages
Generally well tolerated; no previously treated patient developed an inhibitor or experienced an anaphylactic reaction