Duplicates removed	8
Excluded at initial screening (e.g. press releases; news reports; not relevant drug/indication)	11
Excluded during initial selection (e.g. preclinical study; reviews; case reports; not randomized trial)	1
Excluded during writing (e.g. reviews; duplicate data; small patient number; nonrandomized/phase I/II trials)	26
Cited efficacy/tolerability articles	4
Cited articles not efficacy/tolerability	19
Search Strategy: EMBASE, MEDLINE and PubMed from 1946 to present. Clinical trial registries/databases and websites were also searched for relevant data. Key words were Lonoctocog, Afstyla, CSL627, rVIII, rFVIII, recombinant, single-chain, hemophilia A, haemophilia A. Records were limited to those in English language. Searches last updated 4 September 2017