Table 2b.

Significant differences between patients and controls in Wnt signaling pathway gene mRNA expression after controlling for age and gender in linear models, and correction for multiple testing

	Gene	Protein names	Specificity	SCZ vs. HC	BD vs. HC	SCZ vs. BD
				B	B	B
Wnt canonical pathway	PSEN1	Presenilin-1	++	−0.03****	−0.02***	0.01
	FZD7	Frizzled-7	++	0.07****	0.07***	0.00
	β-catenin destruction complex
	FRAT2	GSK-3-binding protein FRAT2	+++	−0.13****	−0.11***	0.02
	CSNK2A2	Casein kinase II subunit alpha	++	−0.05***	−0.05****	−0.01
	CSNK2B	Casein kinase II subunit beta	++	0.07****	0.06****	−0.02
	β-catenin degradation complex
	CACYBP	Calcyclin-binding protein isoform 2	+++	−0.09****	−0.06**	0.03
	FBXW11	F-box/WD repeat-containing protein 11	++	−0.04****	−0.02*	0.02
	CUL1	Cullin-1	++	−0.02	−0.06****	0.05**
	RBX1	E3 ubiquitin-protein ligase RBX1	++	0.06*	0.13****	−0.07*
	β-catenin nuclear regulation
	CHD8	Chromodomain-helicase-DNA-binding protein 8	+++	0.13****	0.09***	−0.04
	CREBBP	CREB-binding protein	+	−0.10****	−0.09****	0.01
	SMAD4	Mothers against decapentaplegic homolog 4	+	−0.09****	−0.06****	−0.03*
	CTBP1	C-terminal binding protein 1	++	−0.03****	−0.01	−0.02*
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	+	−0.03****	−0.03**	0.01
	Transcription targets
	JUN	Transcription factor AP-1	+	−0.10****	−0.10****	0.00
	CCND3	G1/S-specific cyclin-D3	+	0.11****	0.07**	0.04
Wnt non-canonical PCP pathway	RAC2	Ras-related C3 botulinum toxin substrate 2	+	−0.07****	−0.05**	0.03
Wnt non-canonical Ca++ pathway	CAMK2A	Calcium/calmodulin-dependent protein kinase type II subunit alpha	+	0.06****	0.02	0.04**
	CAMK2G	Calcium/calmodulin-dependent protein kinase type II subunit gamma	+	0.01	0.07****	−.05****
	PPP3R1	Calcineurin subunit B type 1	+	0.15****	0.10**	0.05
	PPP3CA	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	+	−0.02	−0.07****	0.04**
	PPP3CC	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform	+	−0.06****	−0.03	−0.03
	PRKCB	Protein kinase C beta type	+	−0.11****	−0.08****	−0.03
	NFATC3	Nuclear factor of activated T cells, cytoplasmic 3	+	0.04****	0.04****	0.00

Gene names are listed according to the HUGO Gene Nomenclature Committee and preferred protein names are given in brackets.

Results are given as effect size estimates from the linear regression analysis after correction for age, sex and BMAL1 expression. Results are significant after Bonferroni correction if p < 3 × 10⁻⁴, and nominally significant if 3 × 10⁻⁴ < p < 0.05.

SCZ schizophrenia, BD bipolar disorder, HC healthy control, B unstandardized regression coefficient

*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 3×10⁻⁴