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. 2018 Mar 5;8:3992. doi: 10.1038/s41598-018-21762-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The minimum spanning tree and ST types distribution characters of C. difficile between children and adults in this study. (A) The minimum spanning tree of isolated C. difficile for MLST typing. Each circle corresponds to ST types, the number of which is indicated for the size of circles. The yellow color area belong to the Clade 1. The lines between circles indicate the similarity between profiles (bold, 5 alleles in common; normal, 4 alleles; dotted, ≤3 alleles). (B) ST constituent ratio of C. difficile strains. Left: children group; right: adults group. (C) The distribution characters of C. difficile ST types for different hospitals in children group. (D) The distribution characters of C. difficile ST types for different hospitals in adults group.