Table 1.
Original diagnosis and IHC classification of 54 sinonasal tumours.
| Initial diagnosis | IHC classification | |||||
|---|---|---|---|---|---|---|
| Tumour entity | Differentiation | N° of Cases | Ck−Ne+ | Ck+Ne+ | Ck+Ne− | Ck−Ne− |
| ONB | Grade I | 3 | 3 | |||
| Grade II | 10 | 5 | 2 | 3a | ||
| Grade III | 6 | 1 | 5 | |||
| Grade IV | 5 | 2 | 2 | 1 | ||
| SNEC | 11 | 8 | 2 | 1 | ||
| SNUC | 19 | 1 | 18b,c | |||
| Total | 24 | 11 | 18 | 24 | 1 | |
Legend. ONB: olfactory neuroblastoma; SNEC: sinonasal neuroendocrine carcinoma; SNUC sinonasal undifferentiated carcinoma; Ck: pan-cytokeratin marker (AE1/AE3); Ne: neuroendocrine markers (synaptophysin/cromogranin); aone case is also SMARCB1-deficient; bone case is also SMARCB1-deficient; cone case shows focal NUT staining.