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. 2018 Mar 5;8:3973. doi: 10.1038/s41598-018-22462-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Exercise could improve walking speed, rotarod coordination and reduce supersensitivity of apomorphine –induced rotation in PD animals. Motor behavior tests were performed for 4 weeks after 6-OHDA lesions and data were obtained from a comparison between PD and PD with exercise animals. (A) Apomorphine-induced rotation was used to confirm that the 6-OHDA lesion induced hemi-parkinsonism; there was no significant difference between PD and PD with exercise with apomorphine initially. (B) There were no differences in body weight between groups. (C) The rotarod test revealed that the short retention time in PD animals could be lengthened by exercise. (D) The data from the rotarod of each group from post-lesion 2nd to 5th weeks were averaged and ploted. (E) The walking speed improved gradually during exercise training and significant improvement could be found after four-weeks of exercise. (F) The data on walking speed of each group from post-lesion 2nd to 5th weeks were averaged and ploted. (G–H) the apomorphine-induced rotation data showing reduced supersensitivity in the PD exercise group.