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. 2018 Mar 5;8:3973. doi: 10.1038/s41598-018-22462-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of dopamine release patterns in PD and PD with exercise animals. (A) Tonic release was very low after the 6-OHDA lesion and the signal could be enhanced by adding nomifensine (a DAT inhibitor). (B) Marked suppression of phasic DA release was seen in 6-OHDA lesioned animals compared to sham (sham, blue solid circle). Enhancement of release could be found after nomifensine infusion especially in the exercise group (green open diamond) compared with 6-OHDA lesioned only animals (pink open triangle).