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. 2018 Mar 5;8:3973. doi: 10.1038/s41598-018-22462-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The deficits of dopamine release probability could be improved after exercise in PD animals. Dopamine release probability measured by using I/O curves generated by evoked DA responses under different stimulation intensities, which indicated that DA release on the 6-OHDA lesioned side could be improved by exercise not only with tonic release (solid diamond vs solid triangle) but also with phasic release (open diamond vs. open triangle). (A) Dopamine release increased in the exercise group and this increment became larger after nomifensine infusion. The dopamine release probability was calculated by different dopamine release concentrations between phasic (10p/25 Hz) and tonic (1p/25 Hz) different stimulation intensities, ([DA] d = [DA]10P-[DA]1P), (B) Linear regression of concentration difference under stimulation intensities 1~10 V. (C) The differences between the phasic and tonic release, referred as releasing probability (slope) increased in exercise animal comparing with those lesioned only. *which indicated a significant difference (p < 0.05) between the PD and PD with exercise animals in Phasic release. #which indicated significant difference (p < 0.05) between the PD and PD with exercise animals in Tonic release.