Table 2.
Upregulated genes in the livers of piglets exposed to both deoxynivalenol (DON) (8 mg/kg) and zerolenone (ZEN) (0.8 mg/kg) dietary treatments
| Gene symbol | Gene description | Log2 FC | p-value | Biological process |
|---|---|---|---|---|
| CLDN4 | Claudin 4 | 2.02 | 0.044 | Regulation of immune system process, acute-phase response |
| CYP26A1 | Cytochrome P450, family 26, subfamily A, polypeptide 1 | 2.13 | 0.012 | Transport and catabolism, Retinol metabolism |
| IGFBP2 | Insulin-like growth factor binding protein 2 | 2.75 | 0.028 | Growth regulation, response to insulin |
| ORM1 | Orosomucoid 1 | 2.25 | 0.028 | Regulation of immune system process |
| FAXDC2 | Fatty acidd hydroxylase domain containing 2 | 2.07 | 0.028 | Fatty acid biosynthetic process |
| SMPD3 | Sphingomyelin phosphodiesterase 3 | 2.21 | 0.033 | Hematopoietic progenitor cell differentiation |
| OAZ3 | Ornithine decarboxylase antizyme 3 | 3.46 | 0.017 | Polyamine metabolic process |
| SCT | secretin | 2.49 | 0.037 | Hormone activity |
| UBD | Ubiquitin D | 3.59 | 0.028 | Positive regulation of apoptotic process |
| CA2 | Carbonic anhydrase 2 | 2.10 | 0.048 | Morphogenesis of an epithelium |
| GAS1 | Growth arrest specific | 2.33 | 0.047 | Regulation of apoptotic process |
| GPT2 | Glutamic-pyruvic transaminase 2 | 5.90 | 0.002 | 2-oxoglutarate metabolic process |
| PCTP | Phosphatidylcholine transfer protein | 2.18 | 0.001 | Intracellular vesicular traffic |
| IL10RB | Interleukin 10 receptor, beta | −2.10 | 0.031 | Cytokine-cytokine receptor interaction |
| IGF1 | Insulin like growth factor 1 | −3.90 | 0.033 | Positive regulation of cell proliferation, activation of MAPK activity |
| OAT | Ornithine aminotransferase | −2.02 | 0.047 | Arginine catabolic process to proline |
| NOCT | Nocturnin | −2.41 | 0.043 | Deadenylation-dependent decapping of nuclear-transcribed mRNA |
| NNMT | Nicotinamide N-methyl transferase | −4.09 | 0.032 | Promotes epigenetic remodeling in cancer |
| LIPG | Lipase G, endothelial type | −2.27 | 0.043 | Positive regulation of high-density lipoprotein particle clearance |
| SIK1 | Salt inducible kinase 1 | −2.24 | 0.011 | Glucagon signaling pathway |
| TRHDE | Thyrotropin releasing hormone degrading enzyme | −2.17 | 0.036 | Regulation of blood pressure, peptide catabolic process |
| SDS | Serine dehydratase | −2.52 | 0.012 | Cellular amino acid metabolic process |
| SLC7A2 | Solute carrier family 7 member 2 | −2.10 | 0.017 | Nitric oxide production involved in inflammatory response |
| SAA | Serum amyloid A | −3.44 | 0.007 | Response to inflammatory stimuli |
| MT1A | Metallothionein 1A | −2.10 | 0.038 | Negative regulation of growth |
| VSIG4 | V-set and immunoglobulin domain containing 4 | −2.10 | 0.006 | Negative regulation of interleukin-2 production |
| ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor 6 | −2.75 | 0.001 | Regulation of Rho protein signal transduction |
| ADORA3 | Adenosine A3 receptor | −2.14 | 0.009 | Neuroactive ligand-receptor interaction |
| PKD1L3 | Polycystic kidney disease 1-like 3 | −2.45 | 0.018 | Transient Receptor Potential Interacting |
| CD207 | CD207 molecule, langerin | −5.60 | 0.034 | Defense response to virus |
| PILRB | Paired immunoglobulin-like type 2 receptor beta | −2.16 | 0.029 | Regulation of the immune system |
| SLA-1 | Src-like-adaptor 1 | −3.15 | 0.049 | Immune response |
| SLA-3 | Src-like-adaptor 3 | −2.00 | 0.020 | Immune response |
| SLA-5 | Src-like-adaptor 5 | −2.46 | 0.013 | Immune response |
| SLA-7 | Src-like-adaptor 7 | −3.27 | 0.012 | Antigen processing and presentation |
| HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 | −10.94 | 0.036 | Isoprenoid biosynthetic process |
| GALP | Galanin like peptide | −14.31 | 0.012 | Neuropeptide signaling pathway |
| UBD | Ubiquitin D | −3.53 | 0.048 | Ubiquitin-dependent protein catabolic process |
| MFSD2A | Major facilitator superfamily domain containing 2A | −2.80 | 0.009 | Establishment of blood-brain barrier |
| SMPD3 | Sphingomyelin phosphodiesterase 3 | −2.01 | 0.036 | Hematopoietic progenitor cell differentiation |
| CGREF1 | Cell growth regulator with EF-hand domain 1 | −2.47 | 0.027 | Calcium ion binding |
| CXCL9 | Chemokine (C-X-C motif) ligand 9 | −3.28 | 0.017 | Inflammatory response |
| HIST1H2B | Histone H2B type 1 | −2.10 | 0.012 | Innate immune response in mucosa |