TABLE 2.
Clinical features and biomarkers that can be used to differentiate between allergic and eosinophilic T2-high severe asthma
|
A: allergic-predominant asthma |
B: eosinophilic-predominant asthma |
|
| 1 | Early onset | Late onset |
| 2 | SPT/RAST+ with clinically significant allergies# | SPT/RAST– or + with no clinically significant allergies |
| 3 | IgE >100 IU·mL−1 | IgE <100 IU·mL−1 |
| 4 | Allergic rhinitis | Nasal polyps |
| 5 | High FENO (30–50 ppb) | Very high FENO (>50 ppb) |
| 6 | Blood eosinophils <300 cells·μL−1 | Blood eosinophils >300 cells·μL−1# |
SPT: skin prick test; RAST: radioallergosorbent test; FENO: exhaled nitric oxide fraction. Check the number of relevant patient characteristics per column. If a patient has more features from column A or B it is more likely that he/she has allergic- or eosinophilic-predominant asthma, respectively. If the patient shares features from both columns, it is more likely that he/she suffers from eosinophilic/allergic overlap asthma. #: obligatory characteristics for allergic and/or eosinophilic asthma.