Fig. 1.

(a) Raman spectroscopy system for surgical guidance of brain cancers, illustrating the use of a Raman spectroscopy probe in situ to distinguish normal brain from cancer (courtesy of ODS Medical Inc.). The bottom right shows a volumetric rendering of the MRI-visible tumor, relative to invasive cancer that extends into the normal brain. (b) Diagnosis of cervical cancer using optical imaging with conventional colposcope (left) and tampon-like device (right). (c) Comparison of image quality between the two technologies in B (B and C courtesy of Dr. Nirmala Ramanujam, Duke University). (d) Device utilizing fluorescence imaging and PDT for skin cancer (D courtesy of MM Optics, Brazil).