Table 2.
Summary of the major studies in English (pub med indexed) on Glycogenic hepatopathy in type 1 diabetes mellitus
| Ref. | Study design | Age/sex | HbA1C | Keto acidosis | Hepatomegaly | Liver abnormality | Normalization of LFTs |
| Chatila et al[43], 1996 | Retrospective Study | Mild Fibrosis (14%) | 11patients (8-A and 3-P) | ||||
| 41/F | NA | NA | No | 20/45/1.4 x ULN/0.35 | Few days to weeks | ||
| 21/F | NA | NA | No | 282/404/0.4 x ULN/0.28 | Few days to weeks | ||
| 58/F | NA | NA | Yes | 35/56/3.2 x ULN/0.40 | Few days to weeks | ||
| 70/F | NA | NA | Yes | 76/NA/NA/1.28 | Few days to weeks | ||
| 36/F | NA | NA | No | 40/86/2.1 x ULN/0.28 | Few days to weeks | ||
| 46/F | NA | NA | Yes | 22/20/1.7 x ULN/N | Few days to weeks | ||
| 23/F | NA | NA | Yes | 265/410/9.5 x ULN/0.40 | Few days to weeks | ||
| 19/F | NA | NA | Yes | 344/532/2.6 x ULN/0.8 | Few days to weeks | ||
| 13/M | NA | NA | Yes | 940/910/2 x ULN/0.30 | Few days to weeks | ||
| 13/M | NA | NA | Yes | 85/NA/0.3 x ULN/0.48 | Few days to weeks | ||
| 15/M | NA | NA | Yes | NA/NA/1.9 x ULN/0.08 | Few days to weeks | ||
| Torbenson et al[44], 2006 | Retrospective Study | 14 patients | |||||
| 19/F | NA | Yes | Yes | 97/83/80/NA | NA | ||
| 1/2M | 13.5 | Yes | Yes | 49/47/182/NA | NA | ||
| 22/F | NA | No | Yes | 48/77/62/NA | NA | ||
| 8/M | NA | No | Yes | Elevated/NA | NA | ||
| 15/F | NA | No | NA | Normal | NA | ||
| 22/M | 16 | Yes | Yes | 1100/360/251/NA | NA | ||
| 25/M | 10.8 | NA | NA | 1629/1128/298/NA | NA | ||
| 16/M | NA | Yes | NA | Elevated/NA | NA | ||
| 20/M | 9.9 | No | yes | N/120/147/NA | NA | ||
| 18/F | 10.8 | No | NA | N/57/N/NA | NA | ||
| 28/M | NA | No | NA | 1099/1544/384/NA | NA | ||
| 34/M | 10.1 | No | Yes | N/NA/N/NA | NA | ||
| 16/M | NA | No | Yes | 1413/1354/476/NA | NA | ||
| 23/F | NA | No | Yes | 255/224/307/NA | NA | ||
| Fitzpatrick et al[45], 2014 | Retrospective | 31 patients | 11(Mean) | Yes-all | 76/76/NA/NA(M) | NA | 14 (73%) Fibrosis |
| 16M/15F | 12Mild and 2Bridging | ||||||
| Median age 15 | Fibrosis | ||||||
| Mukewar et al[46], 2017 | Case control study | 20 patients | 11.4(Mean) 55% | 88.90% | 301/308/170/0.5(M) | 8 mo | 10% Mild fibrosis but no bridging fibrosis |
| 16F/4M | |||||||
| 24-A, 12-P |
T1DM: Type 1 diabetes mellitus; HbA1C: Hemoglobin A1c; AST: Aspartate transferase; ALT: Alanine transferase; ALP: Alkaline phosphatase; T bili: Total bilirubin; M: Male; F: Female; NA: Not available; A: Adults; P: Pediatrics.