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. 2018 Feb 20;2018:7438608. doi: 10.1155/2018/7438608

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Copyright © 2018 Haiyan Tai et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Silencing of FGFRL1 suppresses OC cell proliferation and promotes cell apoptosis. (a) The mRNA and protein expression levels of FGFRL1 were assessed in OC cell lines as well as a nonmalignant ovarian cell line Moody. (b) The qRT-PCR analysis of the FGFRL1 expression after FGFRL1 siRNA interference. (c) Successful FGFRL1 silencing was confirmed by Western blotting. (d) The effect of FGFRL1 on cell proliferation was determined by CCK8 assay. Knockdown of FGFRL1 promoted apoptosis as revealed by caspase-3/7 activity (e) and flow cytometry (f). ^∗ p < 0.05; ^∗∗ p < 0.01.