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SEC of IgG1 mAb B and null cell line culture supernatants. (A) IgG mAb B and (B) null cell line shake flask 1were analysed using size exclusion chromatography to understand the aggregation profile directly in culture. The samples 0.22 µm filtered before running on TSKgel2000SWI column (7.8×300mm) with a flow rate of 0.5 mL min‐1. The detector measured absorbance at 214 nm. Running buffer composed of 100 mmol L‐1 sodium phosphate (monobasic), 400 mmol L‐1 sodium chloride, pH 6.8.
