Table 3. Hazard Ratios of the Incidence of the Study End Points Associated With Hemangioma (Negative Controls).
| Patients With Hemangioma | Control Group | Absolute Risk Difference/1000 Person-Years (95% CI)/ | Hazard Ratio (95% CI) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No. of Patients | No. of Cases | No. of Person-Years | Incidence/1000 Person-Years (95% CI)a | No. of Patients | No. of Cases | No. of Person-Years | Incidence/1000 Person-Years (95% CI)a | |||
| DVT | ||||||||||
| Unadjusted Cox model | 117 762 | 886 | 877 224 | 1.01 (0.94 to 1.08) | 117 762 | 592 | 877 098 | 0.67 (0.62 to 0.73) | 0.34 (0.25 to 0.42) | 1.50 (1.35 to 1.66) |
| Multivariable-adjusted modelb | 117 762 | 886 | 877 224 | 1.01 (0.94 to 1.08) | 117 762 | 592 | 877 098 | 0.67 (0.62 to 0.73) | 0.34 (0.25 to 0.42) | 1.25 (1.12 to 1.40) |
| Cox model using propensity score–matched sample | 116 607 | 877 | 868 419 | 1.01 (0.94 to 1.08) | 116 607 | 795 | 856 236 | 0.93 (0.87 to 0.995) | 0.08 (−0.01 to 0.17) | 1.09 (0.99 to 1.20) |
| PE | ||||||||||
| Unadjusted Cox model | 117 762 | 155 | 881 040 | 0.18 (0.15 to 0.21) | 117 762 | 103 | 879 561 | 0.12 (0.10 to 0.14) | 0.06 (0.02 to 0.09) | 1.50 (1.17 to 1.93) |
| Multivariable-adjusted modelb | 117 762 | 155 | 881 040 | 0.18 (0.15 to 0.21) | 117 762 | 103 | 879 561 | 0.12 (0.10 to 0.14) | 0.06 (0.02 to 0.09) | 1.14 (0.88 to 1.48) |
| Cox model using propensity score–matched sample | 116 607 | 150 | 872 214 | 0.17 (0.15 to 0.20) | 116 607 | 145 | 859 510 | 0.17 (0.14 to 0.20) | 0.00 (−0.04 to 0.04) | 1.02 (0.81 to 1.28) |
| PAD | ||||||||||
| Unadjusted Cox model | 117 762 | 2877 | 867 230 | 3.32 (3.20 to 3.44) | 117 762 | 2864 | 865 277 | 3.31 (3.19 to 3.43) | 0.01 (−0.16 to 0.18) | 1.002 (0.95 to 1.06) |
| Multivariable-adjusted modelb | 117 762 | 2877 | 867 230 | 3.32 (3.20 to 3.44) | 117 762 | 2864 | 865 277 | 3.31 (3.19 to 3.43) | 0.01 (−0.16 to 0.18) | 0.82 (0.78 to 0.87) |
| Cox model using propensity score–matched sample | 116 607 | 2845 | 858 542 | 3.31 (3.19 to 3.44) | 116 607 | 3415 | 842 622 | 4.05 (3.92 to 4.19) | −0.74 (−0.92 to −0.56) | 0.82 (0.78 to 0.86) |
Abbreviations: DVT, deep venous thrombosis; PAD, peripheral artery disease; PE, pulmonary embolism.
a
Exact CIs for Poisson distribution.
b
Model was adjusted for age, sex, index year, hypertension, diabetes, chronic obstructive pulmonary disease, hyperlipidemia, malignancy, heart failure, ischemic heart disease, stroke, chronic renal insufficiency, number of outpatient visits, and varicose veins.